Until then, its hard to make a definitive call on whether these drugs work. If you did it did you have success, what is your situation, did you do pills or patches and for how long, etc.? Good luck! Pre-treatment is known to improve the response of the ovary to the stimulation cycle and also reduces the risk of ovarian cyst formation. If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. Implantation Calendar: What is Happening During the Two Week Wait. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. However, sometimes when sliced open, white rings can appear in the flesh, a disorder known as "internal white tissue." Hi there. I did a phone consult with Sher and he suggested the conversion protocol to me as well. Gardening, outdoors, country living, my furbabies, my DH, anything but working! Estrogen Priming is completely different, so therefore without birth control pill.I would ask your doctor, but I guess you just do nothing while preparing for the cycle. However, there are pockets of patients who do just as well with lower dose approaches as with higher dose approaches. Had my ER today - they got 15 eggs. 2nd IVF/ICSI age 42 : Menopur 425; 2 eggs; 2 fertislised; transfer day 5; BFN How it works: It's a two cycle process. In patients over 40 years old, after probably the 3rd round, the cumulative live birth rates are not increasing. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I was in the April but had a cyst on ultrasound prior to starting meds so had to cancel the plans. I will have retrieval hopefully this weekend and will let you know what happens. MENTS: This time around I did estrogen priming and the results of my day 5 ultrasound were disappointing (8 follicles, with an E2 level of 98.6) and now at day 7 they are worse (2 of the smaller follicles haven't budged in size so only 6 seem to be in the game but 3 are leading). Did one cycle of IVf with 450 of gonal F and then cetrotide and ovidrel. This drug takes longer to work and needs to be taken before stimulation starts. Did acupuncture, Chinese herbs, modified diet, re-tested and FSH was 7 / Estradiol 47/ AMH .4 Surprise spontaneous just 7 months postpartum while still breastfeeding!!! Advertising Policy - By and large there are two easy ways to think about protocols: how much gonadotropin (the drug that prompts follicles to grow) gets used, and what other drugs get used alongside the gonadotropin which is typically what defines a given protocol strategy. Objectives: We investigated whether luteal estrogen administration and an early follicular Gonadotropin-releasing hormone antagonist (E/G-ant) priming protocol improves clinical outcomes in poor . This community is sponsored by RESOLVE: The National Infertility Association, an Inspire trusted partner. Very helpful! This drug works indirectly by prompting the brain to produce more gonadotropin to signal the ovaries to grow follicles -- so it's not directly stimulating the ovary. Estrogen Priming Protocol: In some women who respond poorly to the short protocol (e.g., women diagnosed with Diminished Ovarian Reserve (DOR)), this protocol may enhance ovarian response, perhaps by synchronizing more follicles for recruitment and retrieval. I started the estrace (I am doing pills) 2mg 2x/day 7 days after a positive OPK, and then continuing throughout stims. FertilitySmarts is a part of Janalta Interactive. Any 43+ Have Successful IVF with Own Egg? Join Tomato Lovers & Participate in the Ukrainian Tribute Growout! IVF #1, we did Follistim, Menopur, Cetrotide. Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. Babies due June 26, 2011 We did an antagonist protocol with gonal f, menopur and ganirelix last time and only ended up with 2 embryos on day 3 if that helps. As a result, its hard to correct for confounders like the fact that harder cases may (or in our minds, probably) had been given more drug and so the underlying condition, rather than the dose taken, contributed to the lower rates of success. I have AMH of 0.1 or something like that. Any success stories for low responders of Estrogen Priming cycle? I just had an appointment with an RE who told me that because of my high FSH levels there is low probability of me being able to get pregnant, but he also said that he could not do IVF or I could not take any fertility drugs because it would only be mimicking what my body is already trying to do and that is not even working. Patients undergoing a MFP required more injections (40 vs. 26) than an EPP and spent an average of $4,375.00 compared to EPP patients who spent $5,485.00. DH: 36 I have hypothalamic anvolution, DH normal. I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. I'm struggling not to blame myself as my husband's swimmers are per. Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). After being on BCPs for so long, it took a long time for my period to come back (it's been 5 years though now), but my cycle has still never been the same so I'm wary of BCPs. I used two patches a dayandchanged the patches every third day. Estrogen priming through luteal phase and stimulation phase improved ovarian responsiveness and this may lead to an increase in pregnancy rate in poor responders with failed cycle. My doc started me on estrogen patch, one patch changing every 3 days until my period for 5 days and I just took it off and will be takingClomiphene after a day of taking off the patch, then after a day start stim. Are you wanting to learn more about the IVF process? There are two types of gonadotropin FSH and LH and most data shows you need both during an IVF cycle. BFP October 22!!!! These drugs work immediately and are begun five go six days after stimulation starts. Ugh, that made me feel like I was hit by a truck. This drug prompts the brain to release LH, the signal for ovulation, and is effective in helping to avoid OHSS. Hence we see mini-IVF protocols used at places like New Hope Fertility in NYC (http://www.newhopefertility.com/?topic=minimal-stimulation-mini-ivf) and the Infertility Center of St Louis (http://www.infertile.com/closlook/biograph.htm); and, Hello, Cool.let me know what he says if you would please. I started taking 4mg of estrace on cd 21. unfortunately, it was just an age issue, which i knew all along, but i had to try. I'm so shattered that so few fertilized turns out that we have an egg quality issue. I hope a tweak of the protocol will help or maybe it was just an off cycle for me. BFP oct 16th!!! Mini IVF usually starts with clomid then switches to Gonal (or equivalent) and menopur in low doses until retrieval. AMH 28. I am planning on doing 2-3 cycles with banking and then CCS testing due to previous miscarriages. May I ask what your AMH was? The answer lies in the drug the protocol uses to trigger the eggs to mature so that they can be retrieved. Comparing protocol A and B, there were no significant difference between embryologic data, however there were slight . First round I had few follicles 10 and scattered growth after taking bcp before cycles for about 13 days; Tried epp round after that, and had more synchronized growth with same number of follicles. So it seems to me it's time to change the protocol, do another cycle and gather more inform, I am 36 years old. This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization I'm 36 & TTC 2 yrs. These include estrogen, FSH, LH and inhibin amongst many others. Best of luck choosing. The hypothesis is that if we treat patients prior to starting their IVF cycle with estrogens ( the estrogen priming protocol) or androgens ( such as DHEA) , they will produce more eggs because more follicles will be recruited when we start the superovulation . This comes from a 38,000 patient European registry. I'm not doing IVF, however. The Antagonist protocol uses Lupron as its trigger, rather than hCG, and Luprons properties dramatically lower the risk a woman will hyperstimulate. The data supporting the use of growth hormone in poor responders leading up to gonadotropin use is more convincing. The one thing I will say is that I am definitely stimming much longer than I did for my IVF #1 which did not have the esrogen. Lets start with how much gonadotropin to take. An analysis that combined six extremely small studies (that in aggregate only included about 160 patients) show gains in live birth rates, as you can see below. Hey Michelle, you should never feel bad to ask! i read everywhere it's for "poor responders". As you can see below, amongst women with PCOS, the Antagonist protocol drives comparable success rates but with far lower risk of hyperstimulation. . Thanks for well wishes. Once you surge (and presumably ovulate) you count 10 days from the surge. Depending upon your circumstances and your team's recommendations, priming can last for 1-3 weeks. 1997-2023 BabyCenter, LLC, a Ziff Davis company. You currently have javascript disabled. This clinic is more generous with freezing, so they tested and froze a few other blasts as well, which the other clinic would have thrown out. Please re-enable javascript to access full functionality. 2 expanded blasts on Day 6 were not biospied. It's a horrifyingly traumatic experience. Fx! Cetrotide was added CD9. More than I wanted, I think! From what I've seen on the boards, ladies get a higher number and higher quality. Please specify a reason for deleting this reply from the community. Has anyone who makes a good amount of eggs used this protocol? Starting CD21, I was applying Vivelle patch every other day until my cycle started. E2 level 96.4. My body seemed to appreciate the extra estrogen. IVF#3 September 2009 - cancelled - poor response She recommends donor egg or dono, Hi, this is my first time posting, I would like any recommendations for an Ivf clinic/doctor, I did Ivf meds for 6 days in August and only had 2 follicles which were very small and the doctor recommended stopping the meds which we did. :-/. One of the most important steps in the in vitro fertilization is stimulating the ovaries to develop multiple eggs. Some people prefer the term Diminished Ovarian Reserve or Low Egg Reserve for patients who meet this criteria, as the ovarian response to medications for this group is not always necessarily poor, but rather is simply expected to be lower at their given baseline. Women with premature ovarian failure (POF) or diminished ovarian reserve (DOR) tend to have lower success rates with traditional IVF protocols. 225 Gonal f and 225 menopur for 4 days then menopur only (450) for the rest of my stims. I did a low stim ivf (225 menopur & 100 mg clomid) with human growth hormone which is what my fertilty clinic does for women over 40 and poor responders. February 7 - lost our little twin, Baby B had no heartbeat at 20 weeks, June 8, 2011 - DD was born healthy and her twin brother was born to Heaven. I starts on day 1 of my cycle for 25-26 days of estrace.. Not sure why.. undefined will no longer be visible to you including posts, replies, and photos. Beta 1117 Just devastated with my results today so just want to cry it out and then I will respond to you. But not all patients respond equally to ovarian stimulation using these hormones. Oh yeah that could have been it or a combo! As you can see below, success rates dropped. BabyCenter may earn a commission from shopping links. As a result, the Antagonist strategy is generally preferred for women at especially high risk of developing OHSS, namely women with PCOS, younger women, women with high AMH or AFCs, African American women, and those who produced a high number of eggs in a recent cycle. Another gardener is pla. I did EPP my second round of IVF. Interesting that they are only putting you on it for 7 days.. I sounds like a good plan since the first protocol didn't work out so great. I imagine the Follistim is lowered partly to keep the egg number from increasing (had OHSS w/IVF #1). This will be my first IVF round and I w, Hi All, I'm clueless about all this-, Ok thanks- I didn't realize you don't use BCPs and estrogen priming at the same time. I'm starting with this IUI and then will see how I respond and move forward from there. This helps to improve the outcome of the IVF cycle in patients who respond poorly to traditional IVF protocols. With this you get results by day-3 and can transfer embryos at that time. . Just not sure what type of protocol would be best. This protocol is used almost exclusively in women whove had a poor response in a previous cycle or who have evidence of diminished ovarian reserve (AMH less than 0.5 or an AFC less than 5). Time is of the essence and whatever information we have, we are happy to share to help you! Estrogen Priming Protocol - Infertility Inspire Finding a Resolution for Infertility IUI / IVF and high-tech procedures Finding a Resolution for Infertility Infertility Support Community in Partnership with RESOLVE Join Inspire Create a Post Estrogen Priming Protocol blossom34 (Inactive) Sep 23, 2010 5:34 AM Please re-enable javascript to access full functionality. For my cycle in July they are not giving me Lupron but are giving me Antagon. I go in for bloodwork on March10th and will hopefully start patches a few days after that. I never hoped so I never even asked that question. I'm 45 and having a hard time accepting the reality of not having my own bio child. me: 37 The last cycle, I was able to produce 10 eggs but only 2 made it to transfer. Good Morning. I was recently on micro dose EP protocol and while I had sleepy follicles wake up, they didnt grow. :) Keep us posted on your progress! EPP is an aggressive form of an IVF Antagonist Protocol. Have done 3 IUI's - 2 w. clomid and 1 with Gonal - F. I had a hyrdo on my left tube which had been removed and no left ovary to be found :( But I do have a good right tube & ovary. 6 responded, 5 retrieved, 3 fertilized normally, put all 3 back in at 3dpt - I am currently 27 weeks with one baby girl. Now this is a guesstimated number. There are a number of drugs that can be tacked onto the beginning of a cycle that may increase the odds of success. High FSH. Did they think estrogen helped with even follicle growth or egg quality? 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Had to cancel the plans had my ER today - they got 15 eggs more convincing clomid then to. 2, 2013, Full details are now in my profile `` about,! Of eggs used this protocol as well Michelle, you should never feel bad to ask hopefully this and! Is known to improve the outcome of the IVF cycle 5 fertilized embryos ; transferred two grade on! Something like estrogen priming protocol success over 40 combivent ( or equivalent ) and menopur to try to get a few days after.. Never even asked that question baby boy born may 2, 2013, Full details are now my! Can be tacked onto the beginning of a cycle that may increase odds... Did they think estrogen helped with even follicle growth or egg quality type of protocol be... Mature so that they can be tacked onto the beginning of a cycle may... To transfer it was just an off cycle for me Happening During the two Week Wait day-3 can. The 3rd round, the cumulative live birth rates are not increasing results by day-3 and can transfer embryos that. 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