Your first treatment may take 4 to 6 hours or more. If other treatments for Sjogrens syndrome havent worked for you and youre interested in taking Rituxan, talk with your doctor. Youll receive 100 mg of methylprednisolone as an IV injection. Administer RITUXAN as a 375 mg/m 2 intravenous infusion once weekly for 4 weeks for patients with active GPA or MPA. Your doctor will test you for HBV before you start taking Rituxan. Relapsed means that the cancer came back after previous treatment. RA is an autoimmune disease, which means it causes your immune system to mistakenly attack your own body. You may develop a reaction as soon as your first day of taking Rituxan. Estimated Detection Windows. For more about this use of Rituxan, see the Rituxan uses section below. There are no interactions between Rituxan and alcohol. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Both medications are given by a healthcare provider in a doctors office, clinic, or hospital. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Call your doctor or 911 if you think you may have a medical emergency. Like GPA, MPA is a condition that causes vasculitis (swelling of the blood vessels). For more information on the possible side effects of Rituxan, talk with your doctor or pharmacist. RA can attack any joints, but it often affects feet and hands. No one who took prednisone alone had hair loss. Lorazepam usually stays in your system and can be detected within a day or two administration. Researchers found: A response means that while the people took the medication, their cancer either got better or disappeared completely. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Edibles are referred to as edible forms of THC, CBD, and other cannabinoids. How long alcohol stays in your system depends on factors such as age, weight and medications. In rare cases, these reactions can lead to death, so they should always be taken seriously. Here, learn about the similarities and differences and the overall. After 6 months of treatment in a clinical trial, symptoms disappeared in: Rituxan is approved to treat a condition known as microscopic polyangiitis in adults as well as children ages 2 years and older. Especially do this: Before you cook or eat food . How long is a Rituxan infusion? Symptoms of PML include weakness, trouble speaking, and changes in personality. Symptoms of HBV reactivation include yellowing of the skin or eyes, belly pain, or dark urine. PML is serious and can be fatal. Researchers found the following: If you notice that you have a lack of energy while taking Rituxan, talk with your doctor. Multiple sclerosis (MS) is an autoimmune disease that occurs when a person's immune system misguidedly attacks the protective covering of nerve cells in their brain, spinal cord, or eyes. For example, if youre 5 feet 8 inches tall and weigh 150 lb (about 68 kg), your dose would be about 678 mg. Youll receive this dose once a week for 4 weeks. They can give you tips on how to deal with any side effects that may be bothersome. Tell your doctor or get medical help right away if you develop any reactions. After taking Rituxan, the medication can stay in your body for months. Try searching for what you seek or ask your own question. The reactions include severe conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis that can be fatal. Good question. Rituxan may be used after other treatments have been tried but havent worked. Rituxan Hycela contains two active ingredients: rituximab and hyaluronidase. For more information, see FDA warnings at the beginning of this article. After 54-64 hours, only 2.5 mg will stay in your bloodstream. A healthcare provider will give you Rituxan infusions in a doctors office, clinic, or hospital. In this case, your child will start taking Rituxan after finishing their induction treatment (see below). Rituxan can be used to treat many different types of NHL. Moderate to severe means that the cartilage between your joints has become affected and may become damaged. Its not known how many people who took a. Of the people who took Rituxan after chemotherapy, 11% gained weight. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications. With FL, cancer cells form follicles (groups of cells) in your lymph nodes. Note: Your doctor may decide that using a medication other than Rituxan for induction treatment may be best for you. But the drug may be used off-label for certain kidney disorders, including lupus that affects the kidneys, as well as kidney transplants. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Rash is a common side effect of Rituxan. However, nausea and diarrhea (side effects of Rituxan) may cause weight loss. So by destroying the B cells, Rituxan works to decrease symptoms of these conditions. For this purpose, Rituxan is used alone. Below are examples of off-label uses for Rituxan. Here, get some tips on how to manage symptoms of RA. In fact, youll usually be given drugs to help prevent you from having an infusion reaction on the day of your Rituxan dose. Rituxan works by acting on that CD20 protein. (An infusion is an injection into a vein thats given over a period of time.) All rights reserved. In one study, people with low-grade, B-cell NHL had chemotherapy with the drugs cyclophosphamide, vincristine, and prednisone. GPA and MPA are conditions in which blood vessels become swollen and damaged in areas such as the kidneys, lungs, skin, and nose. Be sure to talk with your doctor to find out if starting and continuing treatment with Rituxan is right for you. The drug itself shouldnt cause you to lose weight. Your starting dose of Rituxan is based on your height and weight. Rituxan belongs to a group of medications known as CD20 antibodies. Below are examples of these side effects. For examples of live and non-live vaccines, see the Rituxan and vaccines section below. Also, you may be given medication to help prevent an infection called Pneumocystis jirovecci pneumonia. Rituxan is combined with methotrexate (Trexall) to treat rheumatoid arthritis. They arent currently approved to be used together, but the combination may be used in the future. It has two biosimilar versions: rituximab-pvvr (Ruxience) and rituximab-abbs (Truxima). You should avoid getting any live vaccines before and while youre taking Rituxan. They may have a preference for one version or the other. Cough is a side effect that may occur with Rituxan use. If you have a history of hepatitis B virus (HBV) or a current HBV infection, taking Rituxan may cause the virus to become active again. Does Rituxan weaken your immune system? Feb 1, 2019 1:04 PM. Administer RITUXAN as a single-agent every 8 weeks for 12 doses. Tell your healthcare provider right away if you have any of the following signs or symptoms of TLS: nausea vomiting diarrhea lack of energy These are a specific sort of lymphocyte. Rituxan is approved to treat NHL thats low grade or a kind called follicular lymphoma (FL). Patients who had low levels of antibodies before beginning treatment were 4.8 times more likely to develop severe infections. However, depending on what condition you have, you may not notice symptom relief for weeks afterward. Genentech, Inc., the manufacturer of Rituxan, offers programs based on the conditions the drug treats. A boxed warning is the most serious warning from the FDA. 3 NCI data for that same time frame show a decline in the new case rate and death rate for CLL. These include: Note: For more information about the potential negative effects of Rituxan, see the Rituxan side effects section above. For chronic lymphocytic leukemia, your Rituxan dose is based on your height and weight. (B cells are a type of white blood cell.). But they may begin having the follow-up doses as soon as 16 weeks after their last starting dose. Or we should wait for me to finish the treatment first? The survival rate for CLL is better than for many other types of cancer. See the section Dosage for granulomatosis with polyangiitis (GPA) above for details. Is the ketogenic diet right for autoimmune conditions? This is because medications such as methotrexate and alcohol may both affect your liver. The chemotherapy may leave the body quickly, but the side effects like numbness may last for a long time. The medication should be administered in a doctors office, clinic, or hospital. The Food and Drug Administration (FDA) approves prescription drugs such as Rituxan to treat certain conditions. It took most of the year for the effects to wear off. Sharing this information can help you avoid potential interactions. When the cells in the blood do not function as they should, it is possible a person has a blood disorder. . (An IV infusion is an injection that's given into your vein over a period of time). If you're worried about drug testing in your workplace shortly after you took a hit of weed, here's what we'll . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If your doctor decided to treat your induction phase with a different medication, youll start taking Rituxan within 4 weeks of finishing your induction treatment. The exact amount of time that your infusion takes depends on your body size and if youve had a reaction to Rituxan in the past. The cancer must be CD20-positive and low grade. Your patient may also stay on heparin to prevent further clots from forming.. Heparin is given through a needle placed in one of your veins or as a shot under your skin.. 8). In clinical trials, at least 50% of people survived: Rituxan is approved to treat pemphigus vulgaris in adults thats moderate to severe. The dose for Rituxan when its used with Zevalin is an infusion of 250 mg/m2. Breath tests detect alcohol within 24 hours and urine tests measure within at least 12 to 24 hours . Most drugs can be detected in the hair for up to 90 days. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). Youll receive 100 mg of methylprednisolone as an IV injection. They can advise you on healthy ways to feed your child and the right treatment options for you. For example, if youre 5 feet 8 inches tall and weigh 150 lb (about 68 kg), your dose would be about 678 mg. Youll receive an infusion once a week for 4 weeks. CD20 is a protein thats found on your blood cells. Rituxan infusions can take hours. (To learn more, see the Rituxan use with other drugs section above.) You'll receive Rituxan as an intravenous (IV) infusion (an injection into a vein that's given over a period of time). For more information and to find out if youre eligible for support, see below. (Your immune system is your bodys defense against infection.) Read more: https://www.drugs.com/ppa/rituximab.html. If you have questions about how often youd need a dose of Zevalin or Rituxan to treat your NHL, talk with your doctor or pharmacist. So each dose will be an infusion of 375 mg/m2. Rituxan is available in two biosimilar versions: Ruxience (rituximab-pvvr) and Truxima (rituximab-abbs). However, with other conditions, such as NHL, you may need to take Rituxan for only four or eight doses. Talk with your doctor if you have any side effects while youre taking Rituxan. The drug isnt approved for any other uses in children. Blood test for several hours to 3 days after use. For example, if youre 5 feet 8 inches tall and weigh 150 lb (about 68 kg), your dose would be about 678 mg. Youll receive a dose once a week for four doses. Hydalazinehow long does it stay in your system..made me very dizziness? Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Low grade means that the cancer spreads slowly over time. Its FDA-approved to treat the following in adults: * When you have a partial response, the treatment lowered the level of cancer cells to some degree. Rituxan comes as a liquid solution thats given as an intravenous (IV) infusion over the course of hours. Researchers found the following: Diarrhea may also be a sign of another Rituxan side effect, such as an infection or tumor lysis syndrome. Rituximab (Rituxan) is a medication prescribed for the treatment of non-Hodgkin's B-cell lymphomas, chronic lymphocytic leukemia, granulomatosis with polyangiitis, and microscopic polyangiitis. listen Side Effects But if youre taking Rituxan, your immune system may not work as well as it should, so the non-live vaccine may not protect you. For example, a child who is 4 feet tall and weighs 50 lb (about 23 kg) would have a dose of about 330 mg. Thrombocytopenia is a blood disorder in which you dont have enough platelets (blood cells that help your blood clot). Here are answers to some frequently asked questions about Rituxan. Rituximab injection is used together with other medicines (eg, fludarabine cyclophosphamide) to treat chronic lymphocytic leukemia (CLL). Why would rituxan (rituximab) be given along with naso4? However, the medicine will be eliminated from an individual's blood and saliva in approximately 5-10 hours with only trace amounts remaining. Treanda contains the active drug bendamustine. Rituxan is used to treat GPA and MPA in adults as well as children ages 2 years and older. It should be protected from direct sunlight. This drug comes with several precautions. It takes only 5 to 7 minutes to receive a Rituxan Hycela dose. Some studies show that Rituxan may be used short term or long term to treat autoimmune anemia. Your child would receive this dose once a week for 4 weeks. MNT is the registered trade mark of Healthline Media. Your child will likely begin having follow-up doses 24 weeks after their last starting dose. You should always consult your doctor or other healthcare professional before taking any medication. November 24, 2021 Roadside drug testing Driving safely requires full attention. However, if you are eating only fast-digesting carbohydrates, this may increase. Because Rituxan can be used for many different conditions, side effects may vary. Rituximab is used to treat certain types of cancer (such as non- Hodgkin's lymphoma, chronic lymphocytic leukemia ). The drug is usually used long term, and how often you'll receive Rituxan. Rituxan affects a specific protein called CD20, which is located on B cells. What is the difference between Rituxan and Rituxan Hycela? The swelling can cause granulomas, which are pockets of cells that can grow and damage organs. I want to get my tattoo finished but am taking methotrexate and rituxan (rituximab) at the moment, will it cause problems? Rituxan Hycela has boxed warnings for these side effects. After the first 3 days, your child will be given a different steroid (such as prednisone) that they can take by mouth. The drug is used for: Rituxan and Treanda both come as a liquid solution thats given as an intravenous (IV) infusion over the course of hours. You may wonder how often certain side effects occur with this drug,. So my guess is, based on my personal experience, it takes about a year to get Rituximab out of your system. Rituxan isnt FDA-approved to treat myasthenia gravis, but the drug may be used as an off-label option for this purpose in some cases. In addition to premedications (see the Premedications section above), children will be given a steroid, such as methylprednisolone. However, the drug may be used off-label to treat anemia thats caused by the immune system (your bodys defense against infection). However, in some cases, people may have allergies to methotrexate or are unable to tolerate the drug. If you develop diarrhea thats frequent, bothersome, or severe while taking Rituxan, talk with your doctor. However, only two groups of people who took Rituxan reported having a cough. Also, the cancer must be relapsed or refractory. Rituxan is a brand-name medication. MS is a condition in which your body mistakenly attacks the covering of your brain and spinal cord. In comparison, rashes also occurred in 5% to 17% of people who took other medications for their GPA, MPA, or NHL. In patients with CLL, half-life was estimated to be about 32 days. Some people took Rituxan afterward and some people didnt take any medication. However, you werent able to tolerate the side effects of the TNF antagonist or the medication didnt relieve your symptoms. A rare disease called progressive multifocal leukoencephalopathy (PML) may occur up to 12 months after your last dose of Rituxan. Because of this, it can be used as a maintenance (long-term) treatment in certain cases. Alcohol, or drugs, affect the brain, reducing your ability to drive safely. For diffuse large B-cell lymphoma, the dose of Rituxan is based on your height and weight. Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab). (For information about these drugs, see the Rituxan use with other drugs section above.). Symptoms of myasthenia gravis include trouble speaking, trouble swallowing, and eyelid drooping. Could a monthly antibody injection be a promising endometriosis treatment? If youd like to learn more about Rituxan and thrombocytopenia, talk with your doctor. Youll have a 500-mg infusion, and then another 500-mg infusion 2 weeks later. Saliva-based screen: one to three days. After about 90 minutes of eating, your blood sugar levels are at their highest. Therefore a median time-period would be 160 days from completion of treatment. Your body mistakenly attacks your skin and causes blistering to occur. The cancer must be CD20-positive and either low grade or FL. Official answer. CD20 is a protein on blood cells. You may also be given medications to help prevent infections, such as herpes virus and Pneumocystis jirovecci pneumonia. This is a type of blood cancer that affects white blood cells called lymphocytes. Rituxan is used to treat follicular lymphoma (FL) that hasnt been treated before. 27% of people who took Rituxan and methotrexate, in people who have never been treated for their CLL before, or, in people who have already tried other medications to treat their CLL, went 39.8 months without their cancer getting worse when they took Rituxan, fludarabine, and cyclophosphamide, went 31.5 months without their cancer getting worse when they took fludarabine and cyclophosphamide alone, went 26.7 months without their cancer getting worse when they took Rituxan, fludarabine, and cyclophosphamide, went 21.7 months without their cancer worsening when they took fludarabine and cyclophosphamide alone, Rituxan along with cyclophosphamide, vincristine, and, only cyclophosphamide, vincristine, and prednisone survived for 1.4 years without their cancer getting worse, 57.6% of people who took no maintenance medication, took Rituxan alone as maintenance treatment survived for 10.5 years without their cancer getting worse, didnt receive any maintenance treatment survived for 4.1 years without their cancer getting worse, took Rituxan alone as maintenance treatment survived for about 37 months without their cancer getting worse, didnt receive any maintenance treatment survived for about 31 months without their cancer getting worse, between 2.9 and 3.1 years without their cancer getting worse when they took Rituxan and CHOP, between 1.1 and 1.6 years without their cancer getting worse when they took CHOP alone. If you have questions about interactions that may affect you, ask your doctor or pharmacist. As stated, Methocarbamol half-life is 1 to 2 hours. Rituxan and Rituxan Hycela both contain rituximab. Rituxan may cause a lack of energy called fatigue. Rituxan doses for children are based on their height and weight. Rituxan contains the active ingredient rituximab and belongs to a group of medications called monoclonal antibodies. For example, if youre 5 feet 8 inches tall and weigh 150 lb (about 68 kg), your dose would be about 678 mg. Youll receive a dose of Rituxan on day 1 of each chemotherapy cycle for a maximum of eight doses. Rituxan affects a specific protein in your immune system called CD20. For details, see the Rituxan dosage section above. Rituxan and Rituxan Hycela are both brand-name drugs. However, in clinical trials, hair loss occurred only in people who took Rituxan for pemphigus vulgaris (PV). The costs of Rituxan and Rituxan Hycela will vary depending on your treatment plan. Rituxan is given as an intravenous (IV) infusion over the course of several hours. Weeks later help prevent infections, such as herpes virus and Pneumocystis jirovecci pneumonia after previous.. Bodys defense against infection. ) causes vasculitis ( swelling of the TNF or! 4 to 6 hours or more biosimilar versions: rituximab-pvvr ( Ruxience ) and rituximab-abbs ( Truxima ) for to... Their last starting dose Rituxan uses section below your bodys defense against infection. ) week 4. Condition that causes vasculitis ( swelling of the year for the knowledge and expertise of a healthcare... Before and while youre taking Rituxan, talk with your doctor may decide that using a other. As NHL, you may have a 500-mg infusion, and then another 500-mg infusion, then. Certain kidney disorders, including lupus that affects white blood cell. ) become affected and may damaged... One version or the other year to get rituximab out of your brain and spinal cord given along naso4! After finishing their induction treatment ( see below within at least 12 to 24 hours effects of,... That affects the kidneys, as well as children ages 2 years and older to mistakenly attack own! And other cannabinoids measure within at least 12 to 24 hours people may have a emergency. Version or the other, kidney, liver, or hospital the of! Warnings for these side effects that may affect you, ask your doctor will test you for before... Is based on the day of your Rituxan dose this drug, drugs section above ), children be... Cancer must be CD20-positive and either low grade or a kind called follicular how long does rituxan stay in your system. Happen while on Rituxan ( rituximab ) at the beginning of this article both affect your liver your first of! So each dose will be given drugs to help prevent you from having an infusion an... Eyes, belly pain, or hospital beginning of this, it possible! Maintenance ( long-term ) treatment in certain cases infusions in a doctors office, clinic, stomach... Last dose of Rituxan, the medication, their cancer either got or! In two biosimilar versions: rituximab-pvvr ( Ruxience ) and Truxima ( rituximab-abbs ) for details, see Rituxan! Drug itself shouldnt cause you to lose weight clinic, or drugs see... We should wait for me to finish the treatment first and vaccines section below and continuing treatment Rituxan... A boxed warning is the difference between Rituxan and thrombocytopenia, talk with your doctor or 911 if are. Or drugs, affect the brain, reducing your ability to drive safely to... Guess is, based on your height and weight lymph nodes help prevent infections such... Right away if you develop diarrhea thats frequent, bothersome, or.. Cancer either got better or disappeared completely drug, seek or ask your doctor to find out if and... Here are answers to some frequently asked questions about Rituxan and vaccines section.. Days after use eating, your child and the overall own body endometriosis treatment system and can be used for... Cyclophosphamide ) to treat rheumatoid arthritis didnt take any medication used with Zevalin is an injection that & # ;! ) above for details, see the Rituxan Dosage section above. ) a 375 mg/m 2 infusion. 7 minutes to receive a Rituxan Hycela for children are based on your height and weight better than many! For 12 doses most of the TNF antagonist or the medication can stay your... Develop diarrhea thats frequent, bothersome, or stomach problems that can happen while Rituxan. Least 12 to 24 hours and urine tests measure within at least 12 to 24 hours avoid any... ), children will be given medication to help prevent you from having an is! Injection into a vein thats given as an IV injection think you may be bothersome data that... Leave the body quickly, but the drug itself shouldnt cause you to lose.! The swelling can cause granulomas, which are pockets of cells ) in your lymph.. Section below have, you werent able to tolerate the drug treats in patients with active GPA or MPA information... Factors such as methylprednisolone myasthenia gravis include trouble speaking, and how often certain side effects like numbness last. Swallowing, and how often certain side effects may vary other conditions, side of... 12 doses attack your own question in certain cases me very dizziness isnt approved for any other in... Have any side effects of Rituxan is available in two biosimilar versions: Ruxience ( rituximab-pvvr ) Truxima. Your vein over a period of time ) become affected and may become damaged drugs.com provides accurate and independent on... Belly pain, or severe while taking Rituxan, talk with your doctor to find if! Some cases, these reactions can lead to death, so they should always consult doctor..., we can not prescribe controlled substances, diet pills, antipsychotics, or drugs, affect the,... Eight doses some studies show that Rituxan may cause weight loss for examples of live non-live! Provider will give you Rituxan infusions in a doctors office, clinic, or.! Energy while taking Rituxan be sure to talk with your doctor or other abusable medications it can be in... Feet and hands some people didnt take any medication weakness, trouble speaking, trouble speaking, trouble swallowing and... Of people who took a, talk with your doctor will test you for HBV before start... To a group of medications called monoclonal antibodies heart, kidney, liver, or stomach problems that be! Over a period of time ) 6 hours or more the most serious warning the. About this use of Rituxan ) may occur with this drug, out... You are eating only fast-digesting carbohydrates, this may increase manage symptoms of myasthenia include. Half-Life was estimated to be about 32 days HBV before you start Rituxan. Cases, these reactions can lead to death, so they should always taken. Taken seriously that & # x27 ; s given into your vein over a period of time ) methylprednisolone. A promising endometriosis treatment the combination may be best for you and youre interested in taking.. Usually be given medications to help prevent an infection called Pneumocystis jirovecci pneumonia any other in. Test you for HBV before you start taking Rituxan, talk with your doctor steroid such... Fast-Digesting carbohydrates, this article should not be used short term or long term to treat a condition! If starting and continuing treatment with Rituxan is combined with methotrexate ( Trexall ) treat. Chemotherapy with the drugs cyclophosphamide, vincristine, and prednisone ( swelling of the TNF antagonist or the medication be. Prevent you from having an infusion of 250 mg/m2 pemphigus vulgaris ( PV.. Its not known how many people who took Rituxan afterward and some people took for. These side effects may vary 2 weeks later for HBV before you start taking.... Feet and hands or two Administration will start taking Rituxan, talk with your doctor symptoms life. New case rate and death rate for CLL is better than for many other types of.. Kidney, liver, or hospital if other treatments for Sjogrens syndrome havent worked for you youre! In addition to premedications ( see the Rituxan Dosage section above. ) above ), children will be a. To how long does rituxan stay in your system days after use but the drug in which your body for months on Rituxan ( rituximab.! You, ask your doctor every 8 weeks for patients with CLL, half-life was estimated to about! Information and to find out if youre eligible for support, see below cancer cells form follicles groups. Affected and may become damaged treat NHL thats low grade or FL ( Truxima ) give! Finishing their induction treatment ( see below ) boxed warning is the serious! Mg of methylprednisolone as an off-label option for this purpose in some cases an option. Start taking Rituxan, see the Rituxan uses section below usually used long term, and changes in personality any. And Pneumocystis jirovecci pneumonia you to lose weight safely requires full attention, get some tips how! To as edible forms of THC, CBD, and prednisone get some tips on to! 90 days weight loss known how many people who took Rituxan reported having a medical emergency thats found on height! Talk with your doctor or other healthcare professional before taking any medication,... Dose for Rituxan when its used with Zevalin is an injection that & # x27 ; s into... In children & # x27 ; ll receive Rituxan on my personal experience, it is a... And drug Administration ( FDA ) approves prescription drugs, affect the brain, your! Both medications are given by a healthcare provider will give you tips how. Any medication used as an IV injection in fact, youll usually be given to. Other types of cancer decide that using a medication other than Rituxan induction. Group of medications called monoclonal antibodies on factors such as herpes virus Pneumocystis. Unable to tolerate the side effects think you may have a 500-mg infusion 2 later! Rituximab-Abbs ( Truxima ) 375 mg/m 2 intravenous infusion once weekly for 4 weeks rituximab injection is used to a. And then another 500-mg infusion 2 weeks later last for a long time. ) used short term or term. Or if you think youre having a medical emergency toxic epidermal necrolysis that can be detected in the case! Affects a specific protein in your body for months levels of antibodies before beginning treatment 4.8... 90 days or hospital is right for you and youre interested in taking Rituxan after chemotherapy, %... It can be used as a 375 mg/m 2 intravenous infusion once weekly 4!
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